Exploring Annexon, Inc. (ANNX) Investor Profile: Who’s Buying and Why?

With 339 institutional owners holding a significant 116.15% of shares outstanding as of April 2025, Annexon Inc. (ANNX) presents an intriguing case for investors. But who are these major players, and what's driving their investment decisions? Are they swayed by the potential of Annexon's clinical trials, or are other factors at play? Consider that the share price has declined by 73.34% since April 2024, standing at $1.53 as of April 14, 2025. With major holders including Fmr Llc, BlackRock, Inc., and others, understanding their moves could be key to unlocking Annexon's future. Let's delve into the details and uncover the dynamics shaping Annexon's investor landscape.

Annexon, Inc. (ANNX) Who Invests in Annexon, Inc. and Why?

Understanding the investor profile of Annexon, Inc. (ANNX) provides insights into the market's perception of the company and its future prospects. A variety of investors, from retail to institutional, are drawn to Annexon, Inc. for various reasons, which reflect the company's position and potential in the biopharmaceutical industry. Here’s a breakdown of the key investor types and their motivations:

Key Investor Types:

Annexon, Inc.'s shareholder base includes a mix of retail investors, hedge funds, and institutional investors.

• Institutional Investors: These entities, such as mutual funds, pension funds, and insurance companies, represent a significant portion of Annexon, Inc.'s shareholders. As of April 2025, institutional investors hold a substantial 127,429,726 shares. Key institutional holders include:
  • Fmr Llc
  • BlackRock, Inc.
  • Satter Management Co., L.p.
  • Bvf Inc/il
  • Redmile Group, LLC
  • Point72 Asset Management, L.P.
  • Vanguard Group Inc
  • Bain Capital Life Sciences Investors, LLC
  • Bellevue Group AG
  • State Street Corp
• Hedge Funds: Several hedge funds have positions in Annexon, Inc., indicating interest from investors seeking potentially higher returns through active management strategies. Top hedge funds holding ANNX can be identified via holdings channel.
• Retail Investors: Individual investors also hold shares in Annexon, Inc., although their collective ownership is smaller compared to institutional investors. Approximately 24.51% of the company's stock is owned by Public Companies and Individual Investors.

The ownership structure of Annexon Biosciences (ANNX) stock is a mix of institutional, retail, and individual investors.

Investment Motivations:

Investors are attracted to Annexon, Inc. due to several factors, primarily linked to its growth prospects and market position.

• Growth Prospects: Annexon, Inc. is a clinical-stage biopharmaceutical company focused on developing therapies for classical complement-mediated neuroinflammatory diseases. Positive Phase 3 data for ANX005 in treating Guillain-Barré syndrome has significantly boosted investor confidence. Analysts predict a median price target of $12.50, with some forecasts reaching as high as $20.00.
• Pipeline Potential: The company has a rich pipeline of potential candidates, including ANX007 for geographic atrophy and ANX1502 for autoimmune indications. These products are in various stages of clinical trials, offering multiple opportunities for future growth and revenue.
• Strong Financial Position: Annexon, Inc.'s cash position is considered stable, with sufficient capital to cover operational costs until the second half of 2026. As of December 2024, the company had $312 million in cash.
• Analyst Ratings: Analysts following Annexon, Inc. have generally been constructive, with a consensus rating of Strong Buy. H.C. Wainwright, for example, has reiterated a Buy rating with a price target of $30.00, citing promising evidence for ANX005 in treating Guillain-Barré Syndrome (GBS).

Investment Strategies:

The investment strategies employed by Annexon, Inc. investors vary depending on their investment goals and risk tolerance.

• Long-Term Holding: Many institutional investors, such as Fmr Llc and BlackRock, Inc., tend to hold their shares for the long term. This strategy is based on the belief in Annexon, Inc.'s potential for significant growth and value creation over time, driven by its clinical pipeline and market opportunities.
• Short-Term Trading: Hedge funds and other active traders may employ short-term trading strategies to capitalize on stock price fluctuations. These strategies can be driven by news events, clinical trial results, and overall market sentiment.
• Value Investing: Some investors may see Annexon, Inc. as undervalued, particularly given its pipeline and potential market opportunities. As of April 17, 2025, Morningstar estimated a fair value of $3.07, while the stock was trading at $1.46.

Institutional Ownership Trends:

Recent trading activity indicates shifts in institutional ownership. For example, in Q4 2024:

• FMR LLC increased its holdings by 5,662,434 shares (+66.1%).
• BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC reduced its holdings by 3,200,679 shares (-37.9%).
• ADAGE CAPITAL PARTNERS GP, L.L.C. liquidated its entire position, selling 2,840,145 shares (-100.0%).

These changes reflect ongoing assessments of Annexon, Inc.'s prospects and adjustments to portfolio allocations.

ANNX Analyst Ratings

Wall Street analysts have issued reports on $ANNX in the last several months. There have been 1 firms issuing buy ratings on the stock, and 0 firms issuing sell ratings. Here are some recent analyst ratings:

• Cowen & Co. issued a 'Buy' rating on 10/23/2024.

For additional insights into Annexon, Inc.'s background, mission, and operations, you can explore: Annexon, Inc. (ANNX): History, Ownership, Mission, How It Works & Makes Money

Annexon, Inc. (ANNX) Institutional Ownership and Major Shareholders of Annexon, Inc. (ANNX)

Institutional ownership in Annexon, Inc. (ANNX) plays a significant role in the company’s stock dynamics. Examining the top institutional investors, changes in ownership, and their overall impact provides valuable insights into the company’s financial health and strategic direction. For additional background, you might find this resource helpful: Annexon, Inc. (ANNX): History, Ownership, Mission, How It Works & Makes Money.

Here's an overview of Annexon, Inc.'s institutional ownership profile:

Top Institutional Investors:

Identifying the largest institutional holders of Annexon, Inc. (ANNX) stock is crucial for understanding market sentiment and potential influences on stock price. While specific, real-time data on the most current major shareholders and their exact holdings can fluctuate, information is available from financial data providers. Typically, these major holders include:

• Vanguard Group: Often holds a significant percentage due to its large index fund offerings.
• BlackRock Fund Advisors: Another major player, managing a substantial number of shares through various funds.
• RA Capital Management, L.P.: A key investor with a significant stake in the company.

Changes in Ownership:

Recent shifts in institutional ownership can indicate confidence or concern among major investors. Increases in holdings may suggest a positive outlook on Annexon, Inc. (ANNX)’s future prospects, while decreases could signal potential risks or lack of confidence. Here’s a general framework to consider changes in ownership:

• Increased Stakes: When institutional investors increase their positions, it often reflects a belief in the company's long-term growth potential or strategic direction.
• Decreased Stakes: Conversely, a reduction in holdings might indicate concerns about the company's performance, industry trends, or broader economic factors.

Impact of Institutional Investors:

Institutional investors can significantly influence Annexon, Inc. (ANNX)’s stock price and corporate strategy. Their trading activity can lead to price volatility, and their voting power can impact key decisions during shareholder meetings. Consider these points:

• Stock Price Influence: Large trades by institutional investors can create substantial buying or selling pressure, affecting the stock price.
• Strategic Influence: Major shareholders often engage with company management to provide input on strategic decisions, potentially shaping the company's direction.

To illustrate the kind of data that is relevant, consider the following table, noting that the specific values would need to be updated with current information:

Annexon, Inc. (ANNX) Key Investors and Their Impact on Annexon, Inc. (ANNX)

Understanding the investor profile of Annexon, Inc. (ANNX) provides critical insights into the company’s stability, growth potential, and strategic direction. Key investors can significantly influence company decisions and stock performance through their holdings and actions.

While specific, real-time data on all institutional and individual investors is constantly in flux, examining recent trends and major stakeholders offers a valuable perspective. Keep in mind that investor information can change rapidly, and the most up-to-date details are typically available through financial data providers and regulatory filings.

Here’s a look at the types of investors and their potential impact on Annexon, Inc. (ANNX):

• Institutional Investors: These are typically large investment firms, such as mutual funds, hedge funds, pension funds, and insurance companies, that manage substantial amounts of capital. Their investment decisions are often based on in-depth research and analysis.
• Vanguard Group: As of the latest reports, Vanguard holds a significant position in Annexon, Inc. (ANNX). Their investment decisions are generally long-term oriented, focusing on index and passively managed funds.
• BlackRock Fund Advisors: BlackRock is another major institutional investor in Annexon, Inc. (ANNX). Their substantial holdings often reflect a diversified investment strategy across various sectors.
• State Street Corporation: State Street is also among the top institutional holders, reflecting its role as a major asset manager with investments in a wide array of companies.

These institutional investors can influence Annexon, Inc. (ANNX) through:

• Voting Rights: Large institutional holders wield significant voting power, influencing decisions on board elections, executive compensation, and major corporate actions.
• Market Sentiment: Their trading activity can significantly impact stock prices, setting the tone for market sentiment towards Annexon, Inc. (ANNX).
• Engagement with Management: These investors often engage with company management to discuss strategic direction, operational performance, and corporate governance.

Recent moves by major investors, such as increasing or decreasing their stakes, can signal confidence or concern about the company’s prospects. Activist investors may also take positions in Annexon, Inc. (ANNX) to push for specific changes, such as strategic shifts, cost-cutting measures, or corporate restructuring. Monitoring these activities is crucial for understanding potential shifts in Annexon, Inc. (ANNX)’s trajectory.

Financial news outlets and databases like Bloomberg, Yahoo Finance, and SEC filings (Form 4, 13F, etc.) are valuable resources for tracking investor activity and ownership percentages. These sources provide insights into who is buying, selling, and holding Annexon, Inc. (ANNX) stock.

For more insights into Annexon, Inc. (ANNX)'s core values, review Mission Statement, Vision, & Core Values of Annexon, Inc. (ANNX).

Disclaimer: Investment decisions should be based on thorough research and consultation with a financial advisor, considering individual circumstances and risk tolerance. The information provided here is for informational purposes only and should not be considered financial advice.

Keeping an eye on these investors and their actions can provide a clearer picture of Annexon, Inc. (ANNX)'s present and future.

Annexon, Inc. (ANNX) Market Impact and Investor Sentiment

Understanding investor sentiment and market reactions is crucial for evaluating Annexon, Inc. (ANNX). Changes in major shareholders' positions and overall market dynamics significantly influence the company's stock performance and future outlook. Recent ownership changes and large investor moves often trigger immediate market responses, reflecting investor confidence or concern.

Here's an overview of key aspects:

• Investor Sentiment: Current sentiment of major shareholders toward Annexon, Inc. (ANNX) (positive, neutral, or negative).
• Recent Market Reactions: How the stock market has responded to changes in ownership or large investor moves.
• Analyst Perspectives: Insights from analysts on the impact of key investors on Annexon, Inc.'s future.

As of the latest data, institutional ownership represents a significant portion of Annexon, Inc.'s (ANNX) shares. According to recent reports, institutional investors hold approximately 75.8% of the company's outstanding shares. This high percentage suggests that institutional investors have a substantial influence on the stock's price movements.

Here is a breakdown of some key institutional holders:

• Vanguard Group Inc.: Holds 3,989,824 shares, representing about 7.94% ownership.
• BlackRock Inc.: Holds 3,642,135 shares, representing approximately 7.25% ownership.
• RA Capital Management, L.P.: Holds 3,349,933 shares, accounting for roughly 6.67% ownership.
• FMR LLC: Holds 3,214,801 shares, which is around 6.40% ownership.
• State Street Corp: Holds 1,684,948 shares, representing about 3.35% ownership.

These major institutional holdings suggest a strong institutional interest in Annexon, Inc. (ANNX). Recent transactions by these key holders can provide insights into their sentiment:

Significant purchases or sales by major shareholders often lead to noticeable market reactions. For instance, a large purchase can signal confidence in the company's prospects, potentially driving the stock price up. Conversely, a significant sale might indicate concerns, leading to a price decline. Monitoring these transactions is essential for understanding short-term market dynamics.

Analysts' perspectives on Annexon, Inc. (ANNX) often consider the influence of key investors. Positive sentiment from major shareholders can reinforce analysts' positive ratings, while concerns among large investors might prompt a more cautious outlook. Analyst ratings and price targets are frequently updated in response to these ownership changes.

For example, if a major institutional investor like Vanguard or BlackRock increases its stake, analysts might interpret this as a positive signal, reaffirming their buy recommendations. Conversely, if a significant holder reduces its position, analysts might reassess their outlook and potentially lower their ratings.

Understanding the interplay between investor sentiment, market reactions, and analyst perspectives provides a comprehensive view of Annexon, Inc.'s (ANNX) market dynamics. This information is invaluable for current and potential investors looking to make informed decisions.

To gain a deeper understanding of Annexon, Inc.'s core values and strategic direction, explore: Mission Statement, Vision, & Core Values of Annexon, Inc. (ANNX).