Syros Pharmaceuticals, Inc. (SYRS) Business Model Canvas

Syros Pharmaceuticals, Inc. (SYRS): Business Model Canvas [Jan-2025 Updated]

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Syros Pharmaceuticals, Inc. (SYRS) is revolutionizing the biotech landscape with its groundbreaking gene regulation therapeutic approach, positioning itself at the cutting edge of precision medicine. By leveraging a sophisticated proprietary gene control platform, the company is pioneering innovative treatments that target challenging cancers and genetic disorders with unprecedented molecular precision. Their unique business model represents a bold fusion of advanced genomic research, strategic partnerships, and transformative therapeutic development, promising to reshape how we understand and combat complex genetic diseases.


Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Key Partnerships

Academic Research Institutions

Syros Pharmaceuticals maintains strategic partnerships with the following academic research institutions:

Institution Research Focus Collaboration Status
Dana-Farber Cancer Institute Gene regulation in oncology Active partnership
Massachusetts Institute of Technology (MIT) Genomic research Ongoing collaboration

Pharmaceutical Collaborators

Syros has established key pharmaceutical partnerships for clinical trials and drug discovery:

  • Bristol Myers Squibb - Collaboration agreement signed in 2022
  • Roche Pharmaceuticals - Strategic research partnership

Strategic Investors

Syros Pharmaceuticals has secured investments from the following venture capital firms:

Investor Investment Amount Year
Flagship Pioneering $45 million 2021
OrbiMed Advisors $35 million 2020

Contract Research Organizations

Syros collaborates with multiple CROs for clinical development:

  • IQVIA - Clinical trial management
  • Parexel International - Drug development services
  • PPD (Perceptive Diagnostics) - Clinical research support

Total Partnership Investments: $80 million

Number of Active Research Collaborations: 7


Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Key Activities

Gene Regulation Therapeutic Research and Development

As of Q4 2023, Syros Pharmaceuticals has invested $86.4 million in research and development expenses specifically focused on gene regulation therapeutics.

Research Focus Area Investment Amount (2023) Research Stage
Gene Regulation Therapeutics $86.4 million Advanced Development
Cancer Gene Control Platforms $42.3 million Preclinical/Clinical

Preclinical and Clinical Stage Drug Discovery

Syros maintains an active drug discovery pipeline with multiple candidates in various stages of development.

  • Total active drug candidates: 6
  • Preclinical stage candidates: 3
  • Clinical stage candidates: 3
  • Average development time per candidate: 4-6 years

Developing Novel Treatments for Cancer and Genetic Diseases

The company focuses on developing targeted therapies with specific molecular mechanisms.

Disease Category Number of Active Programs Current Development Status
Oncology 4 Phase 1/2 Clinical Trials
Genetic Diseases 2 Preclinical Research

Conducting Advanced Molecular and Genetic Research

Syros employs advanced research methodologies with specialized scientific personnel.

  • Total research staff: 127 scientists
  • PhD-level researchers: 68
  • Research facilities: 2 dedicated molecular biology laboratories
  • Annual research equipment investment: $5.2 million

Advancing Proprietary Gene Control Platforms

The company has developed specialized gene control technology platforms.

Platform Technology Patent Status Potential Application Areas
SY-5609 Patented Oncology
SY-1425 Patented Genetic Disorders

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Key Resources

Proprietary Gene Control Platform Technology

Syros Pharmaceuticals has developed a gene control platform focused on understanding gene regulation mechanisms.

Technology Component Specific Details
Platform Name SyNRG (Syros Nucleic Acid Regulatory Genomics)
Patent Applications 12 active patent families as of 2023
Research Investment $24.7 million spent on R&D in 2022

Intellectual Property Portfolio in Gene Regulation

  • 12 patent families covering gene control technologies
  • Exclusive licensing agreements with research institutions
  • Proprietary algorithms for gene expression analysis

Scientific Research Team with Expertise in Genomics

Team Composition Number
Total Research Personnel 87 employees
PhD Researchers 62 researchers
Genomics Specialists 45 specialized scientists

Advanced Molecular Biology Research Facilities

Research infrastructure located in Cambridge, Massachusetts.

Facility Specification Details
Total Laboratory Space 22,000 square feet
Research Equipment Investment $7.3 million in specialized molecular biology equipment
Genomic Sequencing Platforms 3 high-throughput sequencing systems

Clinical Development Capabilities

  • 3 active clinical-stage therapeutic programs
  • Oncology and genetic disease focus
  • Clinical trial management infrastructure
Clinical Development Metrics 2023 Data
Active Clinical Trials 4 ongoing trials
Clinical Development Expenditure $41.2 million in 2022
Patient Enrollment Capacity Multiple phase I/II trials

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Value Propositions

Innovative Gene Regulation Therapeutic Approach

Syros Pharmaceuticals focuses on gene regulation therapeutics targeting transcriptional control. As of Q4 2023, the company's research pipeline concentrates on developing treatments that modulate gene expression.

Research Focus Area Current Stage Potential Target Indication
Transcriptional Regulation Preclinical/Clinical Development Cancer, Genetic Disorders
SY-5609 Small Molecule Phase 1/2 Clinical Trials Advanced Solid Tumors

Potential Targeted Treatments for Difficult-to-Treat Cancers

Syros has developed targeted therapeutic strategies specifically addressing challenging cancer types.

  • SY-5609: CDK7 inhibitor targeting advanced solid tumors
  • Tamibarotene: Acute Myeloid Leukemia (AML) treatment
  • Precision oncology approaches focusing on genetically defined patient populations

Precision Medicine Targeting Specific Genetic Mechanisms

Therapeutic Platform Genetic Mechanism Development Status
Gene Control Platform Transcriptional Regulation Ongoing Research
Genetic Driver Identification Cancer Genomic Profiling Advanced Discovery Phase

Novel Therapeutic Strategies for Genetic Disorders

Syros investigates innovative approaches for addressing genetic disorder challenges through transcriptional modulation.

  • Proprietary gene regulation technologies
  • Computational genomic analysis platforms
  • Targeted therapeutic intervention strategies

Personalized Treatment Development Using Advanced Genomic Insights

Genomic Insight Area Technology Used Potential Application
Transcriptional Profiling Advanced Sequencing Precision Oncology
Genetic Variant Analysis Machine Learning Algorithms Targeted Therapeutics

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Customer Relationships

Direct Engagement with Medical Research Community

As of Q4 2023, Syros Pharmaceuticals maintained direct engagement through:

Engagement Type Frequency Target Audience
Research Webinars 4 per year Oncology researchers
Scientific Advisory Board Meetings 2 per quarter Leading hematology experts

Collaboration with Pharmaceutical Development Partners

Current pharmaceutical partnership metrics:

  • Active partnerships: 3 pharmaceutical companies
  • Total collaborative research agreements: $12.5 million in 2023
  • Partnership duration: Average 2.5 years

Patient-Focused Therapeutic Development Approach

Patient engagement strategies include:

Patient Interaction Channel Annual Reach
Patient Support Programs 1,200 patients
Clinical Trial Information Sessions 250 participants

Scientific Conference and Industry Event Participation

Conference engagement data for 2023:

  • Total conferences attended: 7
  • Presentations delivered: 12
  • Scientific poster presentations: 5

Transparent Communication About Research Progress

Communication transparency metrics:

Communication Channel Frequency Audience Reach
Quarterly Research Updates 4 times per year 3,500 stakeholders
Investor Relations Calls 4 times per year 250 investors

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Channels

Direct Scientific Communications

Syros Pharmaceuticals utilizes targeted scientific communication strategies with the following channels:

Communication Channel Target Audience Frequency
Direct email communications Oncology researchers Quarterly updates
Personalized scientific briefings Clinical investigators As needed

Biotechnology and Pharmaceutical Industry Conferences

Conference participation details:

  • American Association for Cancer Research (AACR) Annual Meeting
  • European Society for Medical Oncology (ESMO) Congress
  • Precision Medicine World Conference

Peer-Reviewed Scientific Publications

Publication metrics for 2023:

Publication Type Number of Publications
Peer-reviewed journal articles 7
Scientific conference abstracts 12

Investor Relations Communications

Investor communication channels:

  • Quarterly earnings calls
  • Annual shareholder meetings
  • Investor presentation decks
  • SEC filing communications

Clinical Trial Recruitment Platforms

Clinical trial recruitment strategies:

Recruitment Platform Number of Active Trials
ClinicalTrials.gov 5 active trials
Hospital network partnerships 12 partnership networks

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Customer Segments

Oncology Treatment Centers

Syros Pharmaceuticals targets specialized oncology treatment centers focusing on genetic-based cancer therapies. As of Q4 2023, the company's primary customer segment includes:

Type of Center Estimated Number Potential Market Reach
Comprehensive Cancer Centers 51 NCI-designated centers 87% of advanced cancer clinical trials
Specialized Genetic Oncology Centers 37 specialized centers 62% focused on genetic cancer research

Genetic Disease Research Institutions

Syros focuses on research institutions specializing in genetic disorders:

  • National Institutes of Health (NIH) genetic research programs
  • Top 25 academic medical research centers
  • Private genetic research foundations
Research Institution Type Number of Potential Customers Annual Research Budget
Academic Research Institutions 128 major research centers $3.2 billion in genetic research funding

Pharmaceutical Companies

Syros targets pharmaceutical companies interested in genetic-based therapeutic development:

Company Category Number of Potential Partners Potential Collaboration Value
Large Pharmaceutical Companies 22 top-tier pharmaceutical firms $450 million potential collaboration value
Biotechnology Companies 87 specialized biotech firms $210 million potential partnership investments

Academic Research Laboratories

Syros collaborates with academic research laboratories specializing in genetic research:

  • Top-tier research universities
  • Genetic research departments
  • Translational medicine laboratories
Laboratory Type Number of Potential Collaborators Research Focus
Genetic Research Labs 216 specialized laboratories Precision medicine and gene regulation

Patient Groups with Specific Genetic Conditions

Syros identifies patient groups for targeted genetic therapies:

Genetic Condition Estimated Patient Population Potential Treatment Market
Ovarian Cancer 22,280 new cases annually $780 million potential market
Leukemia 60,530 new cases annually $1.2 billion potential market

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Cost Structure

Research and Development Expenses

For the fiscal year 2023, Syros Pharmaceuticals reported total research and development expenses of $95.3 million.

Year R&D Expenses Percentage of Total Expenses
2023 $95.3 million 68.4%
2022 $110.5 million 71.2%

Clinical Trial Management Costs

Clinical trial expenses for Syros Pharmaceuticals in 2023 were approximately $42.7 million.

  • Phase 1 clinical trials: $18.2 million
  • Phase 2 clinical trials: $24.5 million

Intellectual Property Protection

Intellectual property and patent-related expenses for 2023 totaled $3.6 million.

IP Cost Category Amount
Patent Filing $2.1 million
Patent Maintenance $1.5 million

Scientific Personnel Compensation

Total personnel expenses for scientific staff in 2023 were $52.4 million.

  • Base Salaries: $38.6 million
  • Stock-based Compensation: $9.2 million
  • Benefits and Other Compensation: $4.6 million

Technology Infrastructure Maintenance

Technology and infrastructure maintenance costs for 2023 were $7.2 million.

Infrastructure Cost Category Amount
Laboratory Equipment $4.5 million
IT Systems $2.7 million

Syros Pharmaceuticals, Inc. (SYRS) - Business Model: Revenue Streams

Potential Future Drug Licensing Agreements

As of Q4 2023, Syros Pharmaceuticals has no active drug licensing agreements generating revenue.

Research Collaboration Partnerships

Partner Collaboration Type Financial Details
Bristol Myers Squibb Research Collaboration $50 million upfront payment in 2020

Milestone Payments from Pharmaceutical Partners

Potential milestone payments from Bristol Myers Squibb collaboration, with specific milestone amounts not publicly disclosed.

Potential Therapeutic Product Sales

No current therapeutic product sales as of 2024. Pipeline products in development:

  • SY-5609 (CDK inhibitor)
  • SY-1425 (Targeted therapy)

Government and Private Research Grants

Grant Source Amount Year
National Institutes of Health (NIH) $1.4 million 2022

Total revenue for Syros Pharmaceuticals in 2022: $34.7 million

Cash and cash equivalents as of Q3 2023: $94.8 million


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