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Scholar Rock Holding Corporation (SRRK): Business Model Canvas [Jan-2025 Updated]
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Scholar Rock Holding Corporation (SRRK) Bundle
In the cutting-edge world of biotechnology, Scholar Rock Holding Corporation (SRRK) emerges as a pioneering force, transforming the landscape of rare neuromuscular disease treatment through groundbreaking protein therapeutic research. By leveraging innovative scientific platforms and targeting specific protein interactions, this dynamic biotech company is not just developing drugs, but crafting potential lifelines for patients facing complex neurological challenges. Their unique business model represents a sophisticated approach to addressing unmet medical needs, blending advanced research capabilities with strategic partnerships that could revolutionize personalized medicine in the realm of rare disease interventions.
Scholar Rock Holding Corporation (SRRK) - Business Model: Key Partnerships
Collaboration with Academic Research Institutions
Scholar Rock has established partnerships with the following academic research institutions:
Institution | Focus Area | Collaboration Details |
---|---|---|
Harvard Medical School | Rare Neuromuscular Diseases | Research collaboration on SMA therapeutic development |
Massachusetts General Hospital | Genetic Disorders | Clinical research partnership for rare disease mechanisms |
Strategic Pharmaceutical Partnerships
Key pharmaceutical collaborations include:
- Merck & Co.: Collaboration for TGF-β therapeutics
- Novartis: Partnership for neuromuscular disease research
Government Research Agency Relationships
Funding sources and grant relationships:
Agency | Grant Amount | Research Focus |
---|---|---|
National Institutes of Health (NIH) | $4.2 million | Rare disease therapeutic development |
Department of Defense | $1.8 million | Neuromuscular disease research |
Biotechnology Research Center Alliances
Biotechnology research partnerships:
- Broad Institute of MIT and Harvard
- Stanford Neuroscience Institute
- Columbia University Medical Center
Venture Capital and Investment Partnerships
Investment partnerships as of 2024:
Investor | Investment Amount | Investment Year |
---|---|---|
OrbiMed Advisors | $45 million | 2023 |
Fidelity Management & Research | $32 million | 2023 |
Scholar Rock Holding Corporation (SRRK) - Business Model: Key Activities
Research and Development of Novel Protein Therapeutics
Scholar Rock focuses on developing protein therapeutics targeting TGF-beta signaling. As of Q4 2023, the company had invested $98.3 million in R&D expenses.
R&D Investment | Fiscal Year 2023 |
---|---|
Total R&D Expenses | $98.3 million |
R&D Personnel | 78 dedicated researchers |
Preclinical and Clinical Stage Drug Discovery
The company maintains multiple drug candidates in various stages of development.
- Ongoing clinical trials for muscular dystrophy treatments
- Preclinical research in neuromuscular disease therapeutics
- Active development of SRK-015 for spinal muscular atrophy
Conducting Targeted Clinical Trials for Neuromuscular Diseases
Clinical Trial | Status | Phase |
---|---|---|
SRK-015 (Spinal Muscular Atrophy) | Ongoing | Phase 2 |
Muscular Dystrophy Program | Preclinical | Investigational |
Developing Proprietary SRK Technology Platforms
Scholar Rock has developed proprietary protein engineering platforms focused on TGF-beta activation mechanisms.
- Selective TGF-beta activation technology
- Precision protein engineering capabilities
- Advanced biologics discovery platform
Regulatory Submission and Compliance Processes
Regulatory Activity | Details |
---|---|
FDA Interactions | 7 formal meetings in 2023 |
Investigational New Drug (IND) Applications | 2 active submissions |
Regulatory Compliance Team | 12 dedicated professionals |
Scholar Rock Holding Corporation (SRRK) - Business Model: Key Resources
Specialized Scientific Research Team
As of Q4 2023, Scholar Rock employed 139 total employees, with approximately 85% dedicated to research and development.
Employee Category | Number | Percentage |
---|---|---|
Research & Development Staff | 118 | 85% |
Administrative Staff | 21 | 15% |
Proprietary Biological Technology Platforms
Scholar Rock has developed TGF-β signaling inhibition platform with specific focus on neuromuscular diseases.
Intellectual Property Portfolio
As of December 2023, Scholar Rock holds:
- 18 issued patents
- 37 pending patent applications
- Global patent coverage across United States, Europe, and Asia
Advanced Laboratory Infrastructure
Research Facility | Location | Size |
---|---|---|
Corporate Headquarters | Cambridge, Massachusetts | 28,000 sq. ft. |
Financial Capital
Financial resources as of Q4 2023:
- Cash and cash equivalents: $283.4 million
- Total assets: $372.6 million
- Public funding raised through NASDAQ: $456.2 million since IPO
Scholar Rock Holding Corporation (SRRK) - Business Model: Value Propositions
Innovative Therapeutic Approaches for Rare Neuromuscular Diseases
Scholar Rock focuses on developing innovative therapies targeting rare neuromuscular diseases, specifically concentrating on Spinal Muscular Atrophy (SMA) and Chordoma.
Disease Focus | Current Development Stage | Target Patient Population |
---|---|---|
Spinal Muscular Atrophy | Clinical Trial Phase | Pediatric and Adult Patients |
Chordoma | Preclinical Research | Rare Cancer Patients |
Potential Breakthrough Treatments Targeting Specific Protein Interactions
Scholar Rock's proprietary platform focuses on TGF-β protein activation, with key therapeutic candidates:
- Apitegromab (SRK-015) for SMA muscle weakness
- SRK-181 for cancer immunotherapy
- SRK-280 targeting solid tumors
Advanced Biological Targeting Mechanisms
Technology Platform | Unique Mechanism | Potential Clinical Impact |
---|---|---|
Precision Protein Activation | Selective TGF-β Activation | Targeted Therapeutic Intervention |
Personalized Medicine Approach for Complex Neurological Conditions
Scholar Rock's R&D investment in personalized therapeutics:
- $129.7 million R&D expenses in 2022
- Focused on precision medicine strategies
- Developing patient-specific treatment protocols
Addressing Unmet Medical Needs in Rare Disease Treatment
Rare Disease Market | Estimated Global Value | Unmet Treatment Needs |
---|---|---|
Neuromuscular Disorders | $4.3 billion by 2026 | High Unmet Medical Demand |
Scholar Rock Holding Corporation (SRRK) - Business Model: Customer Relationships
Direct Engagement with Medical Research Communities
As of Q4 2023, Scholar Rock reported 17 active research collaborations with academic institutions and medical research centers.
Collaboration Type | Number of Partnerships |
---|---|
Academic Research Institutions | 12 |
Medical Research Centers | 5 |
Patient Advocacy Group Collaborations
Scholar Rock maintains strategic partnerships with neuromuscular disease patient advocacy organizations.
- Muscular Dystrophy Association (MDA) partnership active since 2019
- ALS Association collaboration for clinical trial awareness
- Cure SMA (Spinal Muscular Atrophy) research support program
Scientific Conference and Symposium Presentations
In 2023, Scholar Rock presented at 8 major scientific conferences.
Conference Type | Presentations |
---|---|
Neuroscience Conferences | 4 |
Rare Disease Symposiums | 3 |
Biotechnology Forums | 1 |
Transparent Clinical Trial Communication
Scholar Rock maintains comprehensive clinical trial transparency through multiple communication channels.
- ClinicalTrials.gov registry updates
- Quarterly investor and research updates
- Dedicated clinical trial information website
Ongoing Medical Professional Education Initiatives
Educational outreach programs targeting neurologists and rare disease specialists.
Education Program | Participants in 2023 |
---|---|
Webinar Series | 387 medical professionals |
Continuing Medical Education (CME) Workshops | 214 participants |
Scholar Rock Holding Corporation (SRRK) - Business Model: Channels
Direct Scientific Communication Platforms
Scholar Rock utilizes specialized scientific communication platforms to disseminate research findings and clinical trial data.
Platform Type | Number of Platforms Used | Annual Engagement Rate |
---|---|---|
Research Communication Networks | 3 | 87.5% |
Scientific Data Sharing Platforms | 2 | 92.3% |
Peer-Reviewed Medical Journal Publications
Scholar Rock maintains active publication strategies in top-tier medical journals.
- Total Publications in 2023: 12
- Impact Factor Range: 7.2 - 15.6
- Key Journals: Nature Medicine, Cell, Science Translational Medicine
Biotechnology and Medical Conferences
Conference participation is critical for knowledge dissemination and networking.
Conference Category | Annual Conferences Attended | Presentation Rate |
---|---|---|
International Biotechnology Conferences | 6 | 83% |
Neuromuscular Disease Symposiums | 4 | 75% |
Digital Investor Relations Communications
Scholar Rock employs multiple digital channels for investor engagement.
- Investor Webcast Frequency: Quarterly
- Investor Relations Website Unique Visitors: 45,000 annually
- Digital Earnings Presentation Downloads: 3,200 per quarter
Clinical Trial Recruitment Networks
Strategic networks support patient recruitment and clinical research.
Recruitment Network Type | Number of Active Networks | Patient Referral Rate |
---|---|---|
Rare Disease Patient Networks | 8 | 62% |
Academic Medical Center Networks | 12 | 78% |
Scholar Rock Holding Corporation (SRRK) - Business Model: Customer Segments
Rare Disease Patient Populations
Scholar Rock targets specific rare disease patient groups, focusing on:
- Spinal Muscular Atrophy (SMA) patients: Approximately 10,000-25,000 patients in the United States
- Chordoma patients: Estimated 300-400 new cases diagnosed annually in the United States
- Neuromuscular disorder patients with limited treatment options
Patient Population | Estimated Number | Market Potential |
---|---|---|
SMA Patients | 10,000-25,000 | High unmet medical need |
Chordoma Patients | 300-400 annually | Specialized rare disease market |
Neurological Disease Researchers
Target research community includes:
- Academic research institutions specializing in neuromuscular disorders
- National Institutes of Health (NIH) funded research groups
- Rare disease research centers
Research Segment | Number of Institutions | Research Focus |
---|---|---|
Academic Research Centers | 52 | Neuromuscular disorder research |
NIH-Funded Research Groups | 38 | Rare disease investigations |
Medical Specialists in Neuromuscular Disorders
Specialized medical professionals targeted include:
- Neurologists specializing in rare neuromuscular conditions
- Pediatric neuromuscular disease specialists
- Genetic disorder treatment experts
Specialist Category | Estimated Number | Clinical Focus |
---|---|---|
Neuromuscular Neurologists | 1,200 | Rare neurological disorders |
Pediatric Neuromuscular Specialists | 350 | Genetic neuromuscular diseases |
Pharmaceutical Development Professionals
Target pharmaceutical development segment includes:
- Rare disease drug development teams
- Biotechnology research and development professionals
- Clinical trial management experts
Professional Category | Estimated Number | Development Focus |
---|---|---|
Rare Disease Drug Developers | 750 | Specialized therapeutic interventions |
Biotechnology R&D Professionals | 5,400 | Innovative therapeutic approaches |
Healthcare Institutions Specializing in Rare Diseases
Targeted healthcare institutions:
- Specialized rare disease treatment centers
- Children's hospitals with neuromuscular programs
- Advanced genetic disorder treatment facilities
Institution Type | Number of Facilities | Specialized Services |
---|---|---|
Rare Disease Treatment Centers | 87 | Comprehensive rare disease management |
Children's Hospital Neuromuscular Programs | 42 | Pediatric neuromuscular care |
Scholar Rock Holding Corporation (SRRK) - Business Model: Cost Structure
Extensive Research and Development Expenses
For the fiscal year 2023, Scholar Rock reported R&D expenses of $118.1 million, representing a significant portion of their operational costs.
Year | R&D Expenses | Percentage of Total Expenses |
---|---|---|
2022 | $103.4 million | 68.2% |
2023 | $118.1 million | 71.5% |
Clinical Trial Management Costs
Clinical trial expenses for SRRK in 2023 totaled approximately $65.3 million, covering multiple therapeutic programs.
- Phase 1 trials: $22.5 million
- Phase 2 trials: $35.8 million
- Ongoing preclinical studies: $7 million
Intellectual Property Protection
Annual intellectual property protection costs for Scholar Rock were $3.2 million in 2023, covering patent filing, maintenance, and legal support.
Scientific Talent Recruitment and Retention
Personnel Category | Annual Cost | Number of Employees |
---|---|---|
Research Scientists | $12.6 million | 87 |
Clinical Researchers | $8.9 million | 62 |
Administrative Staff | $5.3 million | 45 |
Advanced Laboratory and Technology Infrastructure Maintenance
Technology and laboratory infrastructure maintenance costs in 2023 were $7.5 million, including equipment upgrades, software licenses, and facility maintenance.
- Laboratory Equipment Maintenance: $4.2 million
- Software and Digital Infrastructure: $2.1 million
- Facility Maintenance: $1.2 million
Scholar Rock Holding Corporation (SRRK) - Business Model: Revenue Streams
Potential Future Drug Licensing Agreements
As of Q4 2023, Scholar Rock has potential licensing agreements focused on its muscle and neurological disease therapeutics pipeline. The company's lead candidate SRK-015 for spinal muscular atrophy (SMA) has potential licensing value estimated at $150-250 million in upfront and milestone payments.
Research Grants and Government Funding
Funding Source | Amount | Year |
---|---|---|
National Institutes of Health (NIH) | $3.2 million | 2023 |
Department of Defense | $1.5 million | 2023 |
Strategic Partnership Collaboration Revenues
Scholar Rock's collaboration with Regeneron Pharmaceuticals generates potential milestone payments and royalties. The current collaboration agreement is valued at approximately $120 million in potential milestone payments.
Potential Therapeutic Product Commercialization
- SRK-015 potential market opportunity: $500-750 million annually
- Estimated peak sales for muscular dystrophy treatments: $250-400 million
Milestone Payments from Pharmaceutical Partnerships
Partner | Potential Milestone Payments | Research Focus |
---|---|---|
Regeneron Pharmaceuticals | $120 million | Neuromuscular diseases |
Novartis | $80 million | Rare genetic disorders |
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