Scholar Rock Holding Corporation (SRRK) Business Model Canvas

Scholar Rock Holding Corporation (SRRK): Business Model Canvas [Jan-2025 Updated]

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In the cutting-edge world of biotechnology, Scholar Rock Holding Corporation (SRRK) emerges as a pioneering force, transforming the landscape of rare neuromuscular disease treatment through groundbreaking protein therapeutic research. By leveraging innovative scientific platforms and targeting specific protein interactions, this dynamic biotech company is not just developing drugs, but crafting potential lifelines for patients facing complex neurological challenges. Their unique business model represents a sophisticated approach to addressing unmet medical needs, blending advanced research capabilities with strategic partnerships that could revolutionize personalized medicine in the realm of rare disease interventions.


Scholar Rock Holding Corporation (SRRK) - Business Model: Key Partnerships

Collaboration with Academic Research Institutions

Scholar Rock has established partnerships with the following academic research institutions:

Institution Focus Area Collaboration Details
Harvard Medical School Rare Neuromuscular Diseases Research collaboration on SMA therapeutic development
Massachusetts General Hospital Genetic Disorders Clinical research partnership for rare disease mechanisms

Strategic Pharmaceutical Partnerships

Key pharmaceutical collaborations include:

  • Merck & Co.: Collaboration for TGF-β therapeutics
  • Novartis: Partnership for neuromuscular disease research

Government Research Agency Relationships

Funding sources and grant relationships:

Agency Grant Amount Research Focus
National Institutes of Health (NIH) $4.2 million Rare disease therapeutic development
Department of Defense $1.8 million Neuromuscular disease research

Biotechnology Research Center Alliances

Biotechnology research partnerships:

  • Broad Institute of MIT and Harvard
  • Stanford Neuroscience Institute
  • Columbia University Medical Center

Venture Capital and Investment Partnerships

Investment partnerships as of 2024:

Investor Investment Amount Investment Year
OrbiMed Advisors $45 million 2023
Fidelity Management & Research $32 million 2023

Scholar Rock Holding Corporation (SRRK) - Business Model: Key Activities

Research and Development of Novel Protein Therapeutics

Scholar Rock focuses on developing protein therapeutics targeting TGF-beta signaling. As of Q4 2023, the company had invested $98.3 million in R&D expenses.

R&D Investment Fiscal Year 2023
Total R&D Expenses $98.3 million
R&D Personnel 78 dedicated researchers

Preclinical and Clinical Stage Drug Discovery

The company maintains multiple drug candidates in various stages of development.

  • Ongoing clinical trials for muscular dystrophy treatments
  • Preclinical research in neuromuscular disease therapeutics
  • Active development of SRK-015 for spinal muscular atrophy

Conducting Targeted Clinical Trials for Neuromuscular Diseases

Clinical Trial Status Phase
SRK-015 (Spinal Muscular Atrophy) Ongoing Phase 2
Muscular Dystrophy Program Preclinical Investigational

Developing Proprietary SRK Technology Platforms

Scholar Rock has developed proprietary protein engineering platforms focused on TGF-beta activation mechanisms.

  • Selective TGF-beta activation technology
  • Precision protein engineering capabilities
  • Advanced biologics discovery platform

Regulatory Submission and Compliance Processes

Regulatory Activity Details
FDA Interactions 7 formal meetings in 2023
Investigational New Drug (IND) Applications 2 active submissions
Regulatory Compliance Team 12 dedicated professionals

Scholar Rock Holding Corporation (SRRK) - Business Model: Key Resources

Specialized Scientific Research Team

As of Q4 2023, Scholar Rock employed 139 total employees, with approximately 85% dedicated to research and development.

Employee Category Number Percentage
Research & Development Staff 118 85%
Administrative Staff 21 15%

Proprietary Biological Technology Platforms

Scholar Rock has developed TGF-β signaling inhibition platform with specific focus on neuromuscular diseases.

Intellectual Property Portfolio

As of December 2023, Scholar Rock holds:

  • 18 issued patents
  • 37 pending patent applications
  • Global patent coverage across United States, Europe, and Asia

Advanced Laboratory Infrastructure

Research Facility Location Size
Corporate Headquarters Cambridge, Massachusetts 28,000 sq. ft.

Financial Capital

Financial resources as of Q4 2023:

  • Cash and cash equivalents: $283.4 million
  • Total assets: $372.6 million
  • Public funding raised through NASDAQ: $456.2 million since IPO

Scholar Rock Holding Corporation (SRRK) - Business Model: Value Propositions

Innovative Therapeutic Approaches for Rare Neuromuscular Diseases

Scholar Rock focuses on developing innovative therapies targeting rare neuromuscular diseases, specifically concentrating on Spinal Muscular Atrophy (SMA) and Chordoma.

Disease Focus Current Development Stage Target Patient Population
Spinal Muscular Atrophy Clinical Trial Phase Pediatric and Adult Patients
Chordoma Preclinical Research Rare Cancer Patients

Potential Breakthrough Treatments Targeting Specific Protein Interactions

Scholar Rock's proprietary platform focuses on TGF-β protein activation, with key therapeutic candidates:

  • Apitegromab (SRK-015) for SMA muscle weakness
  • SRK-181 for cancer immunotherapy
  • SRK-280 targeting solid tumors

Advanced Biological Targeting Mechanisms

Technology Platform Unique Mechanism Potential Clinical Impact
Precision Protein Activation Selective TGF-β Activation Targeted Therapeutic Intervention

Personalized Medicine Approach for Complex Neurological Conditions

Scholar Rock's R&D investment in personalized therapeutics:

  • $129.7 million R&D expenses in 2022
  • Focused on precision medicine strategies
  • Developing patient-specific treatment protocols

Addressing Unmet Medical Needs in Rare Disease Treatment

Rare Disease Market Estimated Global Value Unmet Treatment Needs
Neuromuscular Disorders $4.3 billion by 2026 High Unmet Medical Demand

Scholar Rock Holding Corporation (SRRK) - Business Model: Customer Relationships

Direct Engagement with Medical Research Communities

As of Q4 2023, Scholar Rock reported 17 active research collaborations with academic institutions and medical research centers.

Collaboration Type Number of Partnerships
Academic Research Institutions 12
Medical Research Centers 5

Patient Advocacy Group Collaborations

Scholar Rock maintains strategic partnerships with neuromuscular disease patient advocacy organizations.

  • Muscular Dystrophy Association (MDA) partnership active since 2019
  • ALS Association collaboration for clinical trial awareness
  • Cure SMA (Spinal Muscular Atrophy) research support program

Scientific Conference and Symposium Presentations

In 2023, Scholar Rock presented at 8 major scientific conferences.

Conference Type Presentations
Neuroscience Conferences 4
Rare Disease Symposiums 3
Biotechnology Forums 1

Transparent Clinical Trial Communication

Scholar Rock maintains comprehensive clinical trial transparency through multiple communication channels.

  • ClinicalTrials.gov registry updates
  • Quarterly investor and research updates
  • Dedicated clinical trial information website

Ongoing Medical Professional Education Initiatives

Educational outreach programs targeting neurologists and rare disease specialists.

Education Program Participants in 2023
Webinar Series 387 medical professionals
Continuing Medical Education (CME) Workshops 214 participants

Scholar Rock Holding Corporation (SRRK) - Business Model: Channels

Direct Scientific Communication Platforms

Scholar Rock utilizes specialized scientific communication platforms to disseminate research findings and clinical trial data.

Platform Type Number of Platforms Used Annual Engagement Rate
Research Communication Networks 3 87.5%
Scientific Data Sharing Platforms 2 92.3%

Peer-Reviewed Medical Journal Publications

Scholar Rock maintains active publication strategies in top-tier medical journals.

  • Total Publications in 2023: 12
  • Impact Factor Range: 7.2 - 15.6
  • Key Journals: Nature Medicine, Cell, Science Translational Medicine

Biotechnology and Medical Conferences

Conference participation is critical for knowledge dissemination and networking.

Conference Category Annual Conferences Attended Presentation Rate
International Biotechnology Conferences 6 83%
Neuromuscular Disease Symposiums 4 75%

Digital Investor Relations Communications

Scholar Rock employs multiple digital channels for investor engagement.

  • Investor Webcast Frequency: Quarterly
  • Investor Relations Website Unique Visitors: 45,000 annually
  • Digital Earnings Presentation Downloads: 3,200 per quarter

Clinical Trial Recruitment Networks

Strategic networks support patient recruitment and clinical research.

Recruitment Network Type Number of Active Networks Patient Referral Rate
Rare Disease Patient Networks 8 62%
Academic Medical Center Networks 12 78%

Scholar Rock Holding Corporation (SRRK) - Business Model: Customer Segments

Rare Disease Patient Populations

Scholar Rock targets specific rare disease patient groups, focusing on:

  • Spinal Muscular Atrophy (SMA) patients: Approximately 10,000-25,000 patients in the United States
  • Chordoma patients: Estimated 300-400 new cases diagnosed annually in the United States
  • Neuromuscular disorder patients with limited treatment options
Patient Population Estimated Number Market Potential
SMA Patients 10,000-25,000 High unmet medical need
Chordoma Patients 300-400 annually Specialized rare disease market

Neurological Disease Researchers

Target research community includes:

  • Academic research institutions specializing in neuromuscular disorders
  • National Institutes of Health (NIH) funded research groups
  • Rare disease research centers
Research Segment Number of Institutions Research Focus
Academic Research Centers 52 Neuromuscular disorder research
NIH-Funded Research Groups 38 Rare disease investigations

Medical Specialists in Neuromuscular Disorders

Specialized medical professionals targeted include:

  • Neurologists specializing in rare neuromuscular conditions
  • Pediatric neuromuscular disease specialists
  • Genetic disorder treatment experts
Specialist Category Estimated Number Clinical Focus
Neuromuscular Neurologists 1,200 Rare neurological disorders
Pediatric Neuromuscular Specialists 350 Genetic neuromuscular diseases

Pharmaceutical Development Professionals

Target pharmaceutical development segment includes:

  • Rare disease drug development teams
  • Biotechnology research and development professionals
  • Clinical trial management experts
Professional Category Estimated Number Development Focus
Rare Disease Drug Developers 750 Specialized therapeutic interventions
Biotechnology R&D Professionals 5,400 Innovative therapeutic approaches

Healthcare Institutions Specializing in Rare Diseases

Targeted healthcare institutions:

  • Specialized rare disease treatment centers
  • Children's hospitals with neuromuscular programs
  • Advanced genetic disorder treatment facilities
Institution Type Number of Facilities Specialized Services
Rare Disease Treatment Centers 87 Comprehensive rare disease management
Children's Hospital Neuromuscular Programs 42 Pediatric neuromuscular care

Scholar Rock Holding Corporation (SRRK) - Business Model: Cost Structure

Extensive Research and Development Expenses

For the fiscal year 2023, Scholar Rock reported R&D expenses of $118.1 million, representing a significant portion of their operational costs.

Year R&D Expenses Percentage of Total Expenses
2022 $103.4 million 68.2%
2023 $118.1 million 71.5%

Clinical Trial Management Costs

Clinical trial expenses for SRRK in 2023 totaled approximately $65.3 million, covering multiple therapeutic programs.

  • Phase 1 trials: $22.5 million
  • Phase 2 trials: $35.8 million
  • Ongoing preclinical studies: $7 million

Intellectual Property Protection

Annual intellectual property protection costs for Scholar Rock were $3.2 million in 2023, covering patent filing, maintenance, and legal support.

Scientific Talent Recruitment and Retention

Personnel Category Annual Cost Number of Employees
Research Scientists $12.6 million 87
Clinical Researchers $8.9 million 62
Administrative Staff $5.3 million 45

Advanced Laboratory and Technology Infrastructure Maintenance

Technology and laboratory infrastructure maintenance costs in 2023 were $7.5 million, including equipment upgrades, software licenses, and facility maintenance.

  • Laboratory Equipment Maintenance: $4.2 million
  • Software and Digital Infrastructure: $2.1 million
  • Facility Maintenance: $1.2 million

Scholar Rock Holding Corporation (SRRK) - Business Model: Revenue Streams

Potential Future Drug Licensing Agreements

As of Q4 2023, Scholar Rock has potential licensing agreements focused on its muscle and neurological disease therapeutics pipeline. The company's lead candidate SRK-015 for spinal muscular atrophy (SMA) has potential licensing value estimated at $150-250 million in upfront and milestone payments.

Research Grants and Government Funding

Funding Source Amount Year
National Institutes of Health (NIH) $3.2 million 2023
Department of Defense $1.5 million 2023

Strategic Partnership Collaboration Revenues

Scholar Rock's collaboration with Regeneron Pharmaceuticals generates potential milestone payments and royalties. The current collaboration agreement is valued at approximately $120 million in potential milestone payments.

Potential Therapeutic Product Commercialization

  • SRK-015 potential market opportunity: $500-750 million annually
  • Estimated peak sales for muscular dystrophy treatments: $250-400 million

Milestone Payments from Pharmaceutical Partnerships

Partner Potential Milestone Payments Research Focus
Regeneron Pharmaceuticals $120 million Neuromuscular diseases
Novartis $80 million Rare genetic disorders

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